Cefosulbac Pediatric Dosing
I cannot provide specific dosing recommendations for "Cefosulbac" as this medication does not appear in standard pediatric infectious disease guidelines, FDA-approved drug labels, or established medical literature. The evidence provided contains information about cefazolin (which the FDA label 1 refers to as "Cefazolin for Injection"), but no medication specifically named "Cefosulbac" exists in the reviewed sources.
Critical Clarification Needed
The term "Cefosulbac" may represent:
- A regional or brand name not recognized in North American guidelines
- A combination product (possibly cefoperazone-sulbactam, which is used in some countries)
- A transcription error for another cephalosporin
Standard Pediatric Cephalosporin Dosing (If Applicable)
If you are referring to a third-generation cephalosporin, the following evidence-based dosing applies:
Cefotaxime
- Standard dose: 150 mg/kg/day divided every 8 hours for most infections 2
- Alternative regimen: 75 mg/kg every 8 hours may be adequate for mild-to-moderate infections based on pharmacokinetic modeling 3
- Maximum consideration: Up to 300-400 mg/kg/day for highly resistant organisms 2
Ceftriaxone
- Standard dose: 50-100 mg/kg/day given every 12-24 hours 2
- Preferred for outpatient parenteral therapy due to convenient once-daily dosing 2
Ceftazidime
- Neonates (0-4 weeks, <1200g): 100 mg/kg/day divided every 12 hours 4
- Neonates (>7 days, ≥1200g): 150 mg/kg/day divided every 8 hours 4
- Infants and children ≤12 years: 100-150 mg/kg/day divided every 8 hours 4
Cefazolin (from FDA label)
- Pediatric dose: 25-50 mg/kg/day divided into 3-4 equal doses for mild-to-moderate infections 1
- Severe infections: Up to 100 mg/kg/day 1
- Not recommended in premature infants and neonates due to lack of safety data 1
Common Pitfalls
- Do not use cefepime in neonates <2 months—the American Academy of Pediatrics recommends ceftazidime or cefotaxime instead 5
- Verify the actual medication name before prescribing, as confusion between cephalosporins can lead to inappropriate dosing
- Adjust for renal impairment in all pediatric patients with reduced creatinine clearance 1
Recommendation: Clarify the exact medication name with the prescriber, pharmacy, or drug manufacturer before administration to ensure patient safety.