Testosterone Dose Calculation
To administer 150 mg from a 200 mg/mL testosterone preparation, you need to draw 0.75 mL.
Calculation Method
The calculation is straightforward using the concentration formula:
- Volume needed = Desired dose ÷ Concentration
- Volume = 150 mg ÷ 200 mg/mL = 0.75 mL 1
Practical Administration Details
Supplies needed for injection:
- Use an 18-gauge needle to draw the testosterone from the vial 2
- Use a 21-23 gauge, 1-1.5 inch needle for the actual intramuscular injection 2
- A 1-3 mL syringe (3 mL is most common for typical testosterone doses) 2
- Alcohol prep pads for cleaning the vial top and injection site 2
Injection sites:
- Self-injection can be performed in the anterolateral thigh 3, 2
- Gluteal intramuscular injection when administered by another person 3, 2
- The gluteal muscle can safely accommodate up to 3 mL per injection site 2
Clinical Context for 150 mg Dosing
This 150 mg dose falls within standard testosterone replacement therapy ranges:
- Testosterone enanthate and cypionate are typically dosed at 100-200 mg every 2 weeks or 50-100 mg weekly 3, 2
- A 150 mg dose could represent either a weekly injection or part of a biweekly regimen 3
- Weekly dosing (such as 150 mg weekly) provides more stable testosterone levels compared to biweekly administration 2
Important monitoring considerations:
- Testosterone levels should be measured 2-3 months after treatment initiation or any dose change, checking midway between injections and targeting mid-normal values of 450-600 ng/dL 2, 4
- Injectable testosterone carries a higher risk of erythrocytosis (43.8%) compared to transdermal preparations (15.4%), so hematocrit monitoring is mandatory 2
- The 200 mg biweekly regimen is associated with higher erythrocytosis risk than 100 mg weekly due to greater fluctuation in testosterone levels 5