How should fever‑induced delirium be managed as an acute medical emergency?

Management of Fever-Induced Delirium as an Acute Medical Emergency

Fever-induced delirium must be treated as a medical emergency requiring immediate identification and treatment of the underlying cause, aggressive fever control to normothermia, and multicomponent non-pharmacologic interventions, while avoiding routine antipsychotic use unless the patient has distressing hallucinations or delusions. 1, 2

Immediate Assessment and Stabilization

Rapid Delirium Screening

• Use validated screening tools within 2 minutes: either the Confusion Assessment Method-ICU (CAM-ICU) or Intensive Care Delirium Screening Checklist (ICDSC) to confirm delirium diagnosis 1
• Assess level of arousal first using sedation scales, then evaluate for delirium features including inattention (cardinal feature), altered consciousness, and fluctuating course 1
• Perform repeated assessments throughout the day due to the fluctuating nature of delirium 3

Aggressive Fever Management

• Immediately initiate antipyretic therapy without delay while searching for the fever source, as fever duration correlates with worse outcomes 4
• Target temperature of 36.0-37.5°C using acetaminophen or NSAIDs as first-line agents 4
• Use central temperature monitoring (bladder catheter, esophageal thermistor) when available for accurate measurement 4
• For refractory fever, utilize automated feedback-controlled temperature management devices 4

Identify and Treat Underlying Causes

Systematic Investigation

• Infection is the most common precipitating factor (particularly urinary tract infections and pneumonia), but multiple coexisting causes frequently occur 1
• Obtain chest radiograph for all patients with new fever 4
• Collect at least two sets of blood cultures (60 mL total) 4
• Consider CT imaging if recent surgery to rule out surgical site infections 4
• Perform lumbar puncture if neurological symptoms warrant and not contraindicated 4

Critical Metabolic and Physiologic Corrections

• Immediately correct dehydration, hypoglycemia/hyperglycemia, and electrolyte disturbances, as these worsen delirium 5, 1
• Assess for and manage hypoperfusion, hypoxia, and pain 1
• Important caveat: Asymptomatic bacteriuria with delirium should NOT be treated with antibiotics, as this does not improve mental status and may lead to C. difficile infection 3

Medication Review

• Discontinue or minimize deliriogenic medications, particularly benzodiazepines, which are a common modifiable risk factor 1
• Review all psychoactive medications and consider alternatives 1

Non-Pharmacologic Multicomponent Interventions (First-Line)

These interventions can prevent approximately one-third of delirium cases and should be implemented immediately for all patients: 1

• Reorientation: Provide orienting communication, visible calendars and clocks, maintain caregiver consistency 1, 5
• Mobilization: Initiate early mobility and physical rehabilitation, which may shorten mechanical ventilation duration and accelerate delirium resolution 1
• Sleep hygiene: Use non-pharmacologic approaches to promote sleep, reduce excessive noise 1
• Sensory optimization: Provide adaptive equipment for vision and hearing impairment 1
• Nutrition and hydration: Maintain adequate intake 1
• Environmental modifications: Provide a quiet room, minimize unnecessary moves between units 1

Pharmacologic Management (Selective Use Only)

When NOT to Use Antipsychotics

• Do NOT routinely use haloperidol or atypical antipsychotics (olanzapine, quetiapine, ziprasidone), as they do not shorten delirium duration, accelerate resolution, or improve mortality 1, 5

Limited Indications for Antipsychotics

• Only use for severe hyperactive delirium with distressing hallucinations, delusions, or fearfulness that causes significant patient distress 1, 5
• Haloperidol 0.5-2 mg IV slow bolus initially for psychotic symptoms 5
• Discontinue immediately once distressful symptoms resolve 5

Alternative Sedation Strategies

• For mechanically ventilated patients: Consider dexmedetomidine over benzodiazepines, as it may improve delirium outcomes and help with hyperactive delirium resolution 1, 5
• Use short-acting sedatives (propofol, dexmedetomidine) rather than benzodiazepines when sedation is required 1

Special Considerations and Pitfalls

Hypoactive Delirium

• Hypoactive delirium is associated with higher morbidity and mortality and is more difficult to detect 1, 3
• Rule out fearful hallucinations/delusions even in hypoactive presentations 1
• Search for and manage underlying risk factors (sepsis, pain, medications, electrolyte imbalances) as the cornerstone of treatment 1

Post-Infectious Period

• Cognitive dysfunction persists after the acute illness peak, as true cognitive impairment is masked during severe illness 3
• Continue monitoring for delirium in the post-infectious recovery period 3
• Note that infection-related delirium may have lower reversibility rates compared to medication-induced or metabolic causes 3

High-Risk Populations Requiring Intensive Monitoring

• Patients ≥65 years old 1
• Those with pre-existing cognitive impairment or dementia (delirium superimposed on dementia leads to accelerated cognitive decline and higher mortality) 1, 3
• Patients with severe illness or hip fracture 1
• Mechanically ventilated patients (60-80% delirium rate) 1

ICU-Specific Management

• Implement the ABCDEF Bundle approach, which has been associated with reduced delirium, shorter ventilation time, and survival benefits 1
• Minimize sedation depth and duration 1
• Avoid drug-induced coma when possible 1