From the Guidelines

Oral antibiotics are a viable treatment option for osteomyelitis, particularly for patients with stable, chronic, or uncomplicated cases.

Clindamycin (300-450 mg every 6 hours) or trimethoprim-sulfamethoxazole (160/800 mg every 12 hours) for a duration of 6-12 weeks, depending on the severity and response to treatment 1.
Alternatively, fluoroquinolones such as ciprofloxacin (500-750 mg every 12 hours) or levofloxacin (500-750 mg every 24 hours) may be used, especially for Gram-negative organisms, with treatment durations ranging from 6-12 weeks 1.

The optimal duration of therapy for osteomyelitis is unknown, but a minimum of 6-8 weeks is recommended 1.
Surgical debridement and drainage of associated soft-tissue abscesses is the mainstay of therapy and should be performed whenever feasible 1.
The choice of antibiotic should be based on in vitro susceptibility, patient allergies, and potential drug interactions or contraindications 1.
Oral antibiotic therapy may be adequate for the treatment of osteomyelitis in a subset of patients, especially those with stable, chronic, or uncomplicated cases 1.

From the Research

Oral antibiotics can be effective in treating osteomyelitis, especially when used in combination with surgical debridement 2, 3.
The choice of oral antibiotic depends on the causative agent, with fluoroquinolones, such as levofloxacin and ciprofloxacin, being effective against gram-positive and gram-negative organisms 2.
A combination of bactericidal oral antibiotics, such as flucloxacillin and rifampicin, can be used to treat osteomyelitis, especially in cases where the causative agent is sensitive to these antibiotics 3.
Oral antibiotic therapy can be used as an alternative to intravenous therapy, especially for prolonged treatment, due to its advantages in terms of convenience, cost, and avoidance of complications associated with long-term IV therapy 4.

Studies have shown that oral antibiotics can be effective in treating osteomyelitis, with cure rates ranging from 60% to 89% 2, 3.
The efficacy of oral antibiotics depends on the specific antibiotic used, the duration of treatment, and the presence of adequate surgical debridement 2, 3.
Oral fluoroquinolones have been shown to be as effective as standard parenteral treatments in several investigations 5.

The optimal duration of antibiotic therapy for osteomyelitis remains undefined, but most investigators treat patients for about six weeks 5.
Oral antibiotic therapy can be used as initial therapy, or as a transition from intravenous therapy, and can also be used for chronic suppression 4.
The route of administration, whether oral or intravenous, depends on the severity of the infection, the presence of orthopedic hardware, and the patient's ability to tolerate oral therapy 4.