Is there a relationship between protein shake consumption and the development or exacerbation of gout (hyperuricemia)?

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Last updated: April 23, 2025View editorial policy

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From the Guidelines

Protein shakes are generally safe for people with gout, but moderation is key, and it is recommended to choose plant-based protein powders like pea, rice, or hemp over whey or casein, as animal proteins can potentially increase uric acid levels. If you have gout, limit your protein shake intake to one serving per day and ensure your total daily protein consumption stays within recommended guidelines (0.8-1.0 grams per kilogram of body weight for most adults) 1. Stay well-hydrated when consuming protein supplements, as water helps flush excess uric acid from your system. Avoid protein powders with added purines, sweeteners, or ingredients that might trigger gout flares. If you're actively experiencing a gout attack, it's best to temporarily avoid protein supplements until symptoms subside. The relationship between protein intake and gout is complex - while some proteins contain purines that break down into uric acid, moderate protein consumption is necessary for overall health. Always consult with your healthcare provider before adding protein supplements to your diet if you have gout, as individual factors like kidney function and medication regimens may affect recommendations 1.

Some key points to consider:

  • Choose plant-based protein powders to minimize the risk of increasing uric acid levels
  • Limit protein shake intake to one serving per day
  • Stay within recommended daily protein consumption guidelines
  • Stay well-hydrated to help flush excess uric acid
  • Avoid protein powders with added purines, sweeteners, or ingredients that might trigger gout flares
  • Temporarily avoid protein supplements during a gout attack
  • Consult with your healthcare provider before adding protein supplements to your diet, considering individual factors like kidney function and medication regimens 1.

It is essential to prioritize a balanced diet and lifestyle to manage gout, and protein supplements should be used judiciously and under medical guidance.

From the Research

Protein Shake and Gout

  • There is no direct evidence in the provided studies that discusses the relationship between protein shakes and gout.
  • However, some studies suggest that diet plays a role in the development and management of gout, including the intake of purine-rich foods and fructose-rich beverages 2, 3.
  • Gout is caused by monosodium urate crystal deposition in joints and tissues, and risk factors include a diet rich in meat and seafood, as well as alcohol intake and obesity 3.
  • Dietary management and medication may potentially achieve enhanced treatment effects for gout, especially for severe patients 2.
  • Some studies suggest that certain nutrients, such as vitamin C, may help reduce the risk of gout 4.
  • It is essential to note that the provided studies do not specifically address the relationship between protein shakes and gout, and more research would be needed to determine any potential effects 2, 3, 5, 6, 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Gout: Rapid Evidence Review.

American family physician, 2020

Research

Recent advances in management of gout.

QJM : monthly journal of the Association of Physicians, 2012

Research

Therapeutic approaches in the treatment of gout.

Seminars in arthritis and rheumatism, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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