Differential Diagnosis
- Single most likely diagnosis
- Hereditary Angioedema (HAE): This condition is characterized by recurrent episodes of non-pitting edema, often triggered by minor trauma or stress, and can involve the extremities, face, and gastrointestinal tract. The patient's history of similar episodes, family history, and the nature of the edema (non-pitting, asymmetrical, and without redness, itching, or pain) strongly suggest HAE.
- Other Likely diagnoses
- Allergic reactions: Although the patient does not exhibit typical symptoms of an allergic reaction (such as itching, redness, or respiratory distress), some allergic reactions can present atypically, especially if they are not mediated by IgE.
- Idiopathic edema: This condition involves recurrent episodes of edema without an identifiable cause, which could be considered given the patient's history of similar episodes.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Sepsis or severe infection: Although the patient does not have a fever or other signs of infection, it is crucial to consider and rule out sepsis or severe infection, as these conditions can present atypically and are life-threatening.
- Anaphylaxis: A severe, life-threatening allergic reaction that can cause edema, among other symptoms. Even though the patient does not exhibit typical anaphylaxis symptoms, this diagnosis should always be considered in cases of acute edema.
- Rare diagnoses
- Acquired Angioedema: This condition is similar to HAE but is not inherited. It can be associated with lymphoproliferative disorders or the use of certain medications.
- Erythema elevatum diutinum: A rare skin condition characterized by recurrent episodes of edema and erythema, often on the extremities.
- Scleroderma or other autoimmune diseases: Although less likely, these conditions can cause edema and should be considered, especially if other symptoms or signs suggestive of an autoimmune process are present.