How should a low‑to‑intermediate‑grade fibromyxoma (myxofibrosarcoma) of the thigh be managed?

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Last updated: February 23, 2026 • View editorial policy

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In a 69‑year‑old female Licensed Practical Nurse who underwent wide local excision of a high‑grade myxofibrosarcoma of the right lower extremity with periosteal shaving, gastrocnemius muscle flap, skin graft and titanium ligation clips that have migrated and are protruding through the skin, now presenting with reactive thrombocytosis, red‑marrow reconversion on MRI, an 11 × 18 mm soleus muscle hematoma, increasing soft‑tissue edema, chronic circumferential leg tightness consistent with compartment hypertonicity, and an acute episode of generalized muscular tetany, what is the most likely diagnosis and what immediate and long‑term management should be pursued?

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