Retatrutide Concentration Calculation
When 36 mg of retatrutide is diluted in 3 mL of normal saline, the resulting concentration is 12 mg/mL.
Calculation Method
The concentration is calculated using the basic formula: concentration = total drug amount ÷ total volume.
- 36 mg ÷ 3 mL = 12 mg/mL
This straightforward calculation provides the final concentration needed for administration. No complex dilution steps or additional preparations are required beyond this basic mathematical relationship.
Clinical Context
While the provided evidence focuses primarily on retatrutide's clinical efficacy and dosing regimens for obesity and type 2 diabetes rather than reconstitution protocols, the mathematical principle for calculating drug concentrations remains universal across all medications 1, 2.
- Retatrutide has been studied in doses ranging from 0.5 mg to 12 mg administered subcutaneously once weekly in clinical trials 1, 2
- The medication demonstrated significant weight reduction (24.2% at 48 weeks with 12 mg dosing) and glycemic control improvements in phase 2 trials 2
Important Considerations
- Verify the specific reconstitution instructions provided by the manufacturer, as pharmaceutical preparations may have specific diluent requirements beyond simple normal saline dilution
- Ensure proper aseptic technique when preparing any injectable medication
- Confirm the intended route of administration, as retatrutide in clinical trials was administered subcutaneously 1, 2