How many years does Nexplanon (Etonogestrel) last after replacement?

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Last updated: May 1, 2025View editorial policy

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From the Guidelines

Nexplanon is typically replaced every 3 years. This duration is based on the FDA approval for its use, as indicated in the study published in the American Journal of Obstetrics and Gynecology in 2019 1. The implant contains etonogestrel, a synthetic progestin, which prevents pregnancy primarily by suppressing ovulation and thickening cervical mucus to prevent sperm from reaching an egg. Some key points to consider about Nexplanon and its replacement include:

  • The failure rate of Nexplanon is 0.2%, indicating its high effectiveness as a contraceptive method 1.
  • While some research may suggest potential extended use, the FDA-approved guideline for replacement is every 3 years to ensure optimal contraceptive protection.
  • Replacement of Nexplanon is a straightforward procedure that can be performed in a healthcare provider's office, allowing for continuous contraception if desired.
  • It's essential for individuals using Nexplanon to follow the recommended replacement schedule to maintain its effectiveness in preventing pregnancy.

From the Research

Nexplanon Replacement

  • The Nexplanon contraceptive implant should be removed by the end of the third year of use 2.
  • There is no indication that Nexplanon needs to be replaced before the third year, as it is designed to provide effective contraception for up to three years 2, 3.
  • Some studies have investigated the use of Nexplanon beyond the FDA-approved duration of three years, with preliminary findings indicating that it continues to be highly effective for an additional year 4.
  • The effectiveness of Nexplanon in preventing pregnancy is high, with some studies reporting a failure rate of 0 per 100 women-years 4.
  • Common side effects of Nexplanon include changes in menstrual bleeding patterns, but it is generally considered a safe and effective method of contraception 2, 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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