Is combining sauerkraut and nattokinase effective in inhibiting NLRP3?

From the Research

Combining sauerkraut and nattokinase may potentially help inhibit NLRP3, but more research is needed to confirm this effect. Sauerkraut is a fermented food rich in probiotics and antioxidants, while nattokinase is an enzyme derived from natto (fermented soybeans). Both have anti-inflammatory properties that could theoretically help inhibit NLRP3 inflammasome activation, as discussed in the context of inflammation and immune response 1.

To try this combination:

• Consume 1/4 to 1/2 cup of unpasteurized sauerkraut daily
• Take 100-200 mg of nattokinase supplement once or twice daily, considering its safety profile as demonstrated in studies such as 2 and 3, which show nattokinase to be well-tolerated and effective in various health conditions.

The potential NLRP3 inhibition may occur through:

1. Probiotics in sauerkraut supporting gut health and reducing inflammation
2. Antioxidants in sauerkraut neutralizing free radicals
3. Nattokinase's fibrinolytic and anti-inflammatory effects, which have been explored in the context of vascular diseases 2 and metabolic health 4.

However, this specific combination has not been extensively studied for NLRP3 inhibition. While generally safe for most people, consult a healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or are taking medications. Recent advancements in delivery systems, such as the use of chitosan/γ-polyglutamic acid microcapsules to enhance nattokinase stability and bioavailability 5, may also be considered in the development of more effective supplementation strategies.