From the Research
No, pseudoexfoliation syndrome does not cause polymegathism (abnormally large red blood cells) or reduce pleomorphism. Pseudoexfoliation syndrome is an age-related condition characterized by the production and accumulation of abnormal fibrillar material in various ocular tissues, particularly in the anterior segment of the eye. It primarily affects the lens, iris, and trabecular meshwork, leading to complications such as glaucoma and increased risk during cataract surgery. The term polymegathism actually refers to variation in cell size, most commonly discussed in relation to corneal endothelial cells, not red blood cells (which would be macrocytosis) 1. Pleomorphism refers to variation in cell shape. Pseudoexfoliation syndrome does not directly impact blood cells or their morphology. Instead, its effects are localized to ocular structures, where the deposited material can obstruct the trabecular meshwork, impair aqueous humor outflow, and potentially lead to increased intraocular pressure and glaucomatous damage, as discussed in a recent study on pseudoexfoliation glaucoma 2. Some key points to consider include:
- Pseudoexfoliation syndrome is a systemic disorder with ocular manifestations, and its effects on the eye can lead to severe visual impairment and blindness 3.
- The syndrome has been associated with genetic factors, such as polymorphisms of the LOXL1 gene, and environmental factors, such as increased exposure to ultraviolet radiation 4.
- Pseudoexfoliation glaucoma is a major complication of pseudoexfoliation syndrome and represents the main cause of identifiable glaucoma worldwide 2.
- Cataract surgery in patients with pseudoexfoliation syndrome is associated with a higher risk of complications due to zonular instability and poor pupil dilation 3. Overall, pseudoexfoliation syndrome is a complex condition that requires careful management to prevent vision loss and other complications.