From the Guidelines
The life expectancy for someone with osteogenesis imperfecta (OI) varies significantly depending on the type and severity of the condition, with most people with mild forms having a normal or near-normal life expectancy, while those with severe forms may have a shortened lifespan due to respiratory problems and other complications 1.
Factors Affecting Life Expectancy
The primary factors affecting longevity in OI patients include:
- Respiratory function
- Skeletal deformities
- Frequency of fractures Early diagnosis, comprehensive care from multidisciplinary teams, and preventive measures to avoid fractures and complications are essential for maximizing both quality of life and life expectancy for people with OI.
Severity of OI and Life Expectancy
The severity of OI plays a significant role in determining life expectancy, with:
- Mild forms (Type I) having a normal or near-normal life expectancy
- Moderate forms (Types IV, V, VI, and VII) having a relatively normal lifespan with appropriate medical care
- Severe forms (Type II and Type III) having a shortened lifespan due to respiratory problems and other complications
Recent Advances in Treatment
Recent advances in treatment, including bisphosphonate medications, surgical interventions, physical therapy, and improved respiratory support, have significantly improved life expectancy for OI patients over the past few decades 1.
Importance of Pulmonary Function Guidance
Pulmonary function guidance is crucial in OI patients, as respiratory impairment can significantly impact quality of life and life expectancy, and may be overlooked in milder cases 1.
From the Research
Osteogenesis Imperfecta Life Expectancy
- Life expectancy for individuals with osteogenesis imperfecta (OI) can vary greatly depending on the severity of the condition and the quality of care received 2.
- With modern treatment approaches, including bisphosphonates, physical therapy, and orthopedic surgery, many individuals with OI can lead active and fulfilling lives, although life expectancy may still be reduced compared to the general population 3, 4, 5.
- The severity of OI, which can range from mild to severe, plays a significant role in determining life expectancy, with more severe forms of the disease often associated with shorter life spans 2.
- Advances in medical and surgical management, such as the use of bisphosphonates to increase bone mineral density and reduce fracture risk, have improved the outlook for individuals with OI, potentially leading to increased life expectancy 3, 6.
- Multidisciplinary care, including physical therapy, medical treatment, and orthopedic surgery as necessary, is crucial for improving quality of life and potentially extending life expectancy for individuals with OI 5.
Factors Influencing Life Expectancy
- The number and severity of fractures, as well as the presence of other complications such as spinal deformities and basilar impression, can impact life expectancy 4, 2.
- Early intervention and aggressive treatment, including the use of bisphosphonates and orthopedic surgery, may help improve life expectancy by reducing the risk of fractures and other complications 3, 4, 6.
- Ongoing research into new treatments, such as innovative therapies targeting the specific altered pathways in OI, may offer further hope for improving life expectancy and quality of life for individuals with this condition 5.