From the Research
Oral minoxidil can be used in patients with Sjögren's syndrome, but caution is advised due to potential concerns and side effects. Patients with Sjögren's syndrome should consult their rheumatologist before starting oral minoxidil. Sjögren's syndrome causes dry mouth (xerostomia), which may be exacerbated by minoxidil's side effects that include dry mouth in some patients, as noted in various studies 1, 2. Additionally, patients with Sjögren's syndrome often have underlying cardiovascular issues, and minoxidil can cause fluid retention, tachycardia, and hypotension, as reported in studies on minoxidil's effects in hypertension treatment 3, 4, 5.
If oral minoxidil is prescribed, it typically starts at a low dose of 0.625-1.25 mg daily, gradually increasing as tolerated while monitoring for side effects. Patients should be aware of potential side effects including:
- Increased body hair growth
- Fluid retention
- Dizziness
- Headaches Regular follow-up appointments are essential to monitor blood pressure, heart rate, and any adverse effects. Adequate hydration is particularly important for Sjögren's patients to manage dry mouth symptoms. Topical minoxidil might be considered as an alternative with potentially fewer systemic effects for patients primarily seeking hair growth benefits.
It's crucial to weigh the benefits of oral minoxidil against its potential risks in patients with Sjögren's syndrome, considering the lack of direct studies on this specific population but drawing from the broader understanding of minoxidil's side effects and the pathophysiology of Sjögren's syndrome 1. Given the potential for exacerbating dry mouth and other cardiovascular concerns, a cautious approach with close monitoring is recommended.