From the Research
The recommended dose for aspirin (acetylsalicylic acid) suppository is 600 mg, as it provides sufficient levels of salicylic acid within 90 minutes to meet or exceed that of oral aspirin. This dose is particularly useful for patients who cannot take oral medications due to nausea, vomiting, or difficulty swallowing. When using aspirin suppositories, it is essential to ensure the suppository is firm enough to insert; if too soft, refrigerate briefly. Insert the suppository into the rectum with the pointed end first, and remain lying down for a few minutes afterward to prevent expulsion. Aspirin works by inhibiting prostaglandin synthesis, reducing inflammation, pain, and fever. However, aspirin should be avoided in children under 16 years for viral illnesses due to the risk of Reye's syndrome, and it's contraindicated in patients with bleeding disorders, peptic ulcers, or aspirin allergies.
The dose of 600 mg is supported by a study published in 2009 1, which compared the salicylic acid levels in normal subjects after rectal versus oral dosing of aspirin. The study found that the rectal suppository provided significantly more salicylic acid into the blood than the oral tablets over 90 minutes.
Some studies suggest that lower doses of aspirin, such as 75-100 mg, may be effective for long-term prevention of myocardial infarction and stroke 2, 3. However, for acute coronary syndromes, a higher initial dose of aspirin is recommended, and the 600 mg suppository dose is a suitable option.
It is also important to note that aspirin suppositories can be used in patients with acute ischemic stroke, and a dose of 160-300 mg is required to achieve rapid inhibition of thromboxane biosynthesis 4. However, the 600 mg suppository dose is still a suitable option, as it provides sufficient levels of salicylic acid within 90 minutes.
In summary, the recommended dose for aspirin suppository is 600 mg, which provides sufficient levels of salicylic acid within 90 minutes to meet or exceed that of oral aspirin. This dose is suitable for patients who cannot take oral medications, and it is essential to follow the proper administration technique to ensure effective treatment.