There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for olanzapine (PO), baclofen (PO) do not address this question.
From the Research
Role of Olanzapine and Baclofen in Intractable Hiccups
- Olanzapine and baclofen have been used in combination to treat intractable hiccups, with significant improvement in quality of life 1.
- Baclofen is a GABA analog that activates inhibitory neurotransmitters, which may block the hiccup stimulus, while olanzapine's exact mechanism is not fully understood but may be related to its effects on serotonin and dopamine receptors 1.
- Baclofen has been shown to be effective in treating intractable hiccups in several studies, including a double-blind randomized controlled trial 2.
- Olanzapine has been used in combination with baclofen to treat intractable hiccups, but its effectiveness as a solo treatment is not well established 1.
- Other pharmacological agents, such as gabapentin, metoclopramide, and chlorpromazine, have also been used to treat intractable hiccups, but the evidence for their effectiveness is limited 3, 4, 5.
Mechanism of Action
- Baclofen's mechanism of action is thought to be related to its activation of GABA receptors, which may block the hiccup stimulus 1, 2.
- Olanzapine's mechanism of action is not fully understood, but may be related to its effects on serotonin and dopamine receptors, which may influence phrenic motoneuronal activity and the reflex arcs involved in hiccup generation 1.
- The exact mechanisms of action of other pharmacological agents used to treat intractable hiccups are not well established, but may be related to their effects on various neurotransmitters and receptors 3, 4, 5.
Clinical Evidence
- The evidence for the effectiveness of olanzapine and baclofen in treating intractable hiccups is limited to case reports and small studies 1, 2.
- Larger, well-designed trials are needed to establish the efficacy and safety of these agents in treating intractable hiccups 3, 4, 5.
- The choice of treatment for intractable hiccups should be individualized based on the patient's underlying comorbidities, etiology of hiccups, and the properties of the available pharmacological agents 4, 5.