What is a hyperechoic mass?

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From the Guidelines

A hyperechoic mass is a structure that appears brighter or whiter than surrounding tissues when viewed on an ultrasound image, often representing fat, fibrous tissue, calcifications, or certain types of tumors, such as lipomas or inflammatory fibroid polyps, as seen in studies 1.

Definition and Characteristics

A hyperechoic mass is characterized by its increased echogenicity, which results from the physical properties of the tissue, particularly its density and acoustic impedance. When ultrasound waves encounter interfaces between tissues with different acoustic properties, they reflect back with varying intensities, creating the characteristic bright appearance.

Clinical Significance

While hyperechoic masses can be benign, they may also represent malignant lesions in some cases, which is why further evaluation through additional imaging or biopsy is often necessary for definitive diagnosis. The location, size, shape, margins, and internal characteristics of the hyperechoic mass, along with clinical context, help determine its significance and guide appropriate management.

Diagnostic Approaches

Endoscopic ultrasound (EUS) has become a valuable tool in characterizing subepithelial lesions, including hyperechoic masses, by determining the layer of origin, size, echogenicity, and presence of blood vessels on Doppler flow, as noted in studies 1. EUS can help narrow down the differential diagnosis and has therapeutic implications for endoscopic resection.

Key Points

  • Hyperechoic masses can represent various types of tissue, including fat, fibrous tissue, calcifications, or certain types of tumors.
  • EUS is a useful tool in characterizing subepithelial lesions, including hyperechoic masses.
  • Further evaluation through additional imaging or biopsy is often necessary for definitive diagnosis.
  • The location, size, shape, margins, and internal characteristics of the hyperechoic mass, along with clinical context, help determine its significance and guide appropriate management, as discussed in studies 1.

From the Research

Definition of Hyperechoic Mass

  • A hyperechoic mass is a type of lesion that appears brighter than the surrounding tissue on ultrasound imaging 2, 3, 4, 5, 6.
  • This is because the mass has a higher echogenicity, meaning it reflects more sound waves back to the ultrasound probe.

Characteristics of Hyperechoic Masses

  • Hyperechoic masses are often benign, but can also be malignant 3, 4, 5, 6.
  • Benign hyperechoic masses can include lesions such as lipoma, hematoma, seroma, fat necrosis, abscess, and pseudoangiomatous stromal hyperplasia 4, 5.
  • Malignant hyperechoic masses can include invasive ductal carcinoma, invasive lobular carcinoma, metastasis, lymphoma, and angiosarcoma 2, 3, 4, 5, 6.

Ultrasound Features of Hyperechoic Masses

  • Hyperechoic masses can have varying ultrasound features, including a hypoechoic center and hyperechoic rim, or a dispersed pattern with hyperechoic areas throughout the lesion 2.
  • Malignant hyperechoic masses are more likely to have non-circumscribed margins, non-parallel orientation, and a hypoechoic area 3, 6.

Importance of Correlation with Other Imaging Modalities

  • Hyperechoic masses should be correlated with mammographic findings and clinical history to determine the need for biopsy 3, 5, 6.
  • Lesions with worrisome features such as a spiculated margin, interval enlargement, interval vascularity, or association with suspicious microcalcifications on mammography require biopsy 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Ultrasonographic hyperechoic lesions of the breast: are they always benign?

Acta radiologica (Stockholm, Sweden : 1987), 2015

Research

Hyperechoic lesions of the breast: radiologic-histopathologic correlation.

AJR. American journal of roentgenology, 2013

Research

Hyperechoic Lesions on Breast Ultrasound: All Things Bright and Beautiful?

The Indian journal of radiology & imaging, 2021

Research

Hyperechoic lesions of the breast: not always benign.

AJR. American journal of roentgenology, 2011

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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