Can zinc supplementation help alleviate tinnitus symptoms in individuals with suspected zinc deficiency?

From the Guidelines

Zinc supplementation is not recommended for treating patients with persistent, bothersome tinnitus, according to the latest clinical practice guidelines. This recommendation is based on randomized controlled trials (RCTs) and systematic reviews, which have methodological concerns but show a preponderance of benefit over harm 1. Although zinc plays important roles in the auditory system, including protecting hair cells in the inner ear from oxidative damage and supporting proper nerve transmission, the current evidence does not support its use in alleviating tinnitus symptoms.

When considering zinc supplementation, it is essential to note that the relationship between zinc and tinnitus is complex, and deficiency might compromise the ear's protective mechanisms and neural signaling. However, the latest guideline recommends against using zinc supplements for treating tinnitus 1. If zinc deficiency is suspected, a daily supplement of 0.5-1 mg/kg per day of elemental zinc (Zn2+), can be given orally for 3-4 months, as recommended for acquired zinc deficiency 1. It is crucial to get zinc levels tested through a blood test before starting supplementation and to be aware of potential side effects, including nausea, vomiting, and interference with copper absorption.

Key points to consider:

• Zinc supplementation is not recommended for treating patients with persistent, bothersome tinnitus 1
• Zinc plays important roles in the auditory system, including protecting hair cells in the inner ear from oxidative damage and supporting proper nerve transmission
• If zinc deficiency is suspected, a daily supplement of 0.5-1 mg/kg per day of elemental zinc (Zn2+) can be given orally for 3-4 months 1
• Comprehensive management of tinnitus should include evaluation by an audiologist or ENT specialist to identify underlying causes and explore additional treatment options.

From the Research

Zinc Supplementation and Tinnitus

• The effectiveness of zinc supplementation in alleviating tinnitus symptoms is a topic of interest, particularly in individuals with suspected zinc deficiency 2, 3, 4, 5, 6.
• Studies suggest that zinc plays a role in cochlear physiology and the synapses of the auditory system, providing a plausible mechanism for its potential effect on tinnitus 3, 5.

Evidence from Clinical Trials

• A randomized, prospective double-blind placebo-controlled trial conducted in 2013 found no significant difference in tinnitus improvement between the zinc and placebo groups 2.
• A review of clinical trials published in 2016 found that the use of oral zinc supplementation did not improve symptoms in adults with tinnitus, with very low-quality evidence 5.
• Another study published in 2002 found that zinc therapy presented no promising effect on tinnitus in patients with normal or low serum zinc levels, although some elderly patients reported relief 6.

Prevalence of Zinc Deficiency in Tinnitus Patients

• The prevalence of zinc deficiency in individuals with tinnitus is reported to range from 2 to 69%, with elderly individuals being more frequently affected 3.
• However, a study published in 2002 found no significant correlation between tinnitus and decreased zinc levels, contradicting previous reports 6.

Conclusion on Effectiveness

• The current evidence suggests that zinc supplementation is not an effective treatment for tinnitus in most patients, although some individuals may experience relief, particularly those with dietary zinc deficiency 2, 4, 5, 6.