How long can Zepbound (generic name) be taken out of the refrigerator?

Storage Guidelines for Zepbound Outside of Refrigeration

Zepbound can be stored at room temperature (up to 86°F/30°C) for up to 21 days after removing it from the refrigerator. 1

Detailed Storage Requirements

Primary Storage

• Store Zepbound in the refrigerator between 36°F to 46°F (2°C to 8°C)
• Keep in the original carton until use to protect from light 1

Room Temperature Storage

• Each single-dose pen or vial can be stored at room temperature up to 86°F (30°C) for a maximum of 21 days
• Once stored at room temperature, Zepbound should not be returned to the refrigerator
• Discard if not used within 21 days after removing from refrigeration 1

Important Precautions

Temperature Considerations

• Do not freeze Zepbound
• Do not use if it has been frozen 1
• Avoid exposure to temperatures above 86°F (30°C)

Visual Inspection Before Use

Before using Zepbound that has been stored outside the refrigerator, inspect to ensure:

• The medication is not frozen
• It remains colorless to slightly yellow
• The solution is not cloudy
• There are no visible particles 1

Common Pitfalls to Avoid

1. Returning to refrigeration: Once stored at room temperature, never return Zepbound to the refrigerator as this can affect stability

2. Temperature monitoring: Household refrigerators often operate outside the recommended temperature range for medications. Consider using a refrigerator thermometer to ensure proper storage conditions 2

3. Extended storage: Exceeding the 21-day room temperature limit may reduce medication effectiveness

4. Temperature extremes: When transporting Zepbound outside, use insulated bags or cooler packs in hot or freezing conditions 2

5. Improper handling: Allow Zepbound to reach room temperature (30-60 minutes) before injection to minimize injection pain 2

Following these storage guidelines will help maintain the efficacy and safety of Zepbound while providing flexibility for travel or daily use.