From the FDA Drug Label
Prior to first use, OZEMPIC should be stored in a refrigerator between 36ºF to 46ºF (2ºC to 8ºC). After first use of the OZEMPIC pen, the pen can be stored for 56 days at controlled room temperature (59°F to 86°F; 15°C to 30°C) or in a refrigerator (36°F to 46°F; 2°C to 8°C).
Storage Requirements for Ozempic:
- Before first use, Ozempic must be refrigerated at a temperature between 36°F to 46°F (2°C to 8°C).
- After the first use, the pen can be stored at room temperature (59°F to 86°F; 15°C to 30°C) or in the refrigerator for up to 56 days.
- Do not freeze Ozempic, and do not use it if it has been frozen.
- Always keep the pen cap on when not in use and protect Ozempic from excessive heat and sunlight 1.
From the Research
Yes, Ozempic (semaglutide) needs to be refrigerated before first use at a temperature between 36°F to 46°F (2°C to 8°C). After first use, you have two storage options: either continue refrigerating it or keep it at room temperature not exceeding 86°F (30°C) for up to 56 days (8 weeks). Never freeze Ozempic and always protect it from light by keeping it in its original packaging. The refrigeration requirement exists because semaglutide is a peptide medication that can degrade when exposed to higher temperatures, which would reduce its effectiveness. The medication contains preservatives that allow for the room temperature storage option after first use, providing convenience for patients who travel or don't always have access to refrigeration. Always discard the pen 56 days after first use, even if medication remains, as the sterility and potency cannot be guaranteed beyond this timeframe.
Storage Considerations
- Before first use, Ozempic should be stored in the refrigerator at a temperature between 36°F to 46°F (2°C to 8°C) 2.
- After first use, Ozempic can be stored at room temperature not exceeding 86°F (30°C) for up to 56 days (8 weeks) 3.
- It's essential to protect Ozempic from light by keeping it in its original packaging.
- Freezing Ozempic is not recommended, as it can affect the medication's potency and sterility.
Medication Stability
- Semaglutide, the active ingredient in Ozempic, is a peptide medication that can degrade when exposed to higher temperatures 4.
- The medication contains preservatives that allow for room temperature storage after first use, providing convenience for patients 5.
- However, it's crucial to follow the recommended storage guidelines to ensure the medication's effectiveness and sterility.
Patient Guidance
- Patients should be advised to store Ozempic in the refrigerator before first use and to follow the recommended storage guidelines after first use.
- Patients who travel or don't always have access to refrigeration can store Ozempic at room temperature for up to 56 days (8 weeks) 6.
- It's essential to educate patients on the importance of proper storage and handling of Ozempic to ensure the medication's effectiveness and safety.