What medications are safe to take for cold symptoms during pregnancy?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: August 10, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Safe Medications for Cold Symptoms During Pregnancy

Acetaminophen (Tylenol) is the safest and most recommended medication for treating cold symptoms like fever and pain during pregnancy, while non-pharmacological approaches should be tried first for other symptoms. 1, 2

First-Line Approaches: Non-Pharmacological Methods

Before turning to medications, pregnant women should try these safer non-pharmacological approaches:

  • Rest and increased fluid intake
  • Humidifier use to relieve congestion
  • Saline nasal irrigation for nasal congestion
  • Honey for cough (not for infants under 1 year)

Safe Medication Options

For Pain and Fever

  • Acetaminophen (Tylenol):
    • Use at the lowest effective dose for the shortest time possible 1
    • FDA-approved for use during pregnancy when used as directed 2
    • Should be used only when medically necessary 3, 4

For Nasal Congestion

  • Saline nasal sprays: Safe and can be used as needed
  • Avoid pseudoephedrine especially in women with hypertension or preeclampsia, and limit use to short-term only if benefits outweigh risks 1

For Cough

  • Dextromethorphan: Generally considered safe for short-term use, but consult healthcare provider before use 1

For Allergic Symptoms

  • Older antihistamines like chlorpheniramine may be used for short periods if necessary
  • Avoid newer antihistamines unless specifically recommended by a healthcare provider 1

Medications to Avoid

  • NSAIDs (ibuprofen, naproxen): Avoid especially after 30 weeks gestation due to risk of premature closure of the fetal ductus arteriosus, oligohydramnios, and potential renal effects 1
  • Multi-symptom cold medications: Often contain multiple active ingredients, alcohol, or high doses of individual components 1
  • Pseudoephedrine: Use with caution and only for short periods if benefits outweigh risks 1

Important Considerations

  1. Acetaminophen safety concerns: While acetaminophen is considered the safest option, recent research suggests potential associations between prolonged use during pregnancy and neurodevelopmental outcomes in children 3, 5, 4, 6. However, short-term use appears to have minimal risk 4.

  2. Label reading: Pregnant women should carefully read labels of all over-the-counter products to understand all ingredients 1, 7.

  3. Healthcare provider consultation: Always check with your healthcare provider before taking any medication during pregnancy 1.

Dosing Guidelines

  • Acetaminophen: Use the lowest effective dose for the shortest possible time 1, 5
  • Standard adult dose: 650 mg per dose 2
  • Do not exceed recommended daily maximum

Common Pitfalls to Avoid

  1. Self-medicating without consulting healthcare provider: Always discuss medication use with your provider first.

  2. Taking combination products: Many cold medications contain multiple ingredients that may not all be necessary or safe.

  3. Extended use of medications: Use medications only for the shortest duration necessary.

  4. Assuming "natural" means safe: Even herbal remedies and supplements should be discussed with healthcare providers before use during pregnancy.

  5. Untreated high fever: High fever itself can pose risks during pregnancy, so appropriate treatment is important.

References

Guideline

Asthma Management During Pregnancy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Paracetamol use in pregnancy: Not as safe as we may think?

Acta obstetricia et gynecologica Scandinavica, 2023

Research

Is acetaminophen safe in pregnancy?

Scandinavian journal of pain, 2017

Research

Treating the common cold during pregnancy.

Canadian family physician Medecin de famille canadien, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.