What is the medical use of Monosodium gluconate?

From the Guidelines

Monosodium gluconate is not directly mentioned in the provided evidence, however, calcium gluconate is mentioned as a commonly used treatment to minimize peripheral vein irritation in patients with bradycardia and cardiac conduction delay 1.

Medical Use of Calcium Gluconate

The medical use of calcium gluconate is to provide calcium supplementation, particularly in cases of calcium channel blocker overdose or beta-blocker overdose, as it helps to counteract the effects of these medications on the heart 1.

• Calcium gluconate is used to minimize peripheral vein irritation, making it a preferred choice over calcium chloride in some cases 1.
• The evidence suggests that calcium gluconate may have hemodynamic benefits in humans, although the results are less consistent compared to animal studies 1.
• Adverse effects of calcium gluconate, such as hypercalcemia, are rare 1.

Comparison to Other Treatments

Other treatments mentioned in the evidence include glucagon and high-dose insulin therapy, which are used to counteract the effects of beta-blocker and calcium channel blocker overdose 1.

• Glucagon is a vasoactive polypeptide that increases heart rate, but its effects are transient and may be associated with side effects such as nausea and vomiting 1.
• High-dose insulin therapy has been shown to improve heart rate, hemodynamic parameters, and mortality in beta-blocker and calcium channel blocker overdose, but its evidence base is of lower quality and may be associated with side effects such as hypoglycemia and hypokalemia 1.

Recommendation

Based on the most recent and highest quality evidence, calcium gluconate is a recommended treatment for patients with bradycardia and cardiac conduction delay, particularly in cases of calcium channel blocker overdose or beta-blocker overdose, due to its ability to minimize peripheral vein irritation and provide calcium supplementation 1.

From the FDA Drug Label

1 INDICATIONS & USAGE

Calcium Gluconate Injection is indicated for pediatric and adult patients for the treatment of acute symptomatic hypocalcemia.

The medical use of Monosodium gluconate is not directly mentioned in the provided drug labels. However, the labels discuss the use of Calcium Gluconate Injection for the treatment of acute symptomatic hypocalcemia. Since Monosodium gluconate is not mentioned, the answer to the question about its medical use cannot be determined from the provided information. The FDA drug label does not answer the question.

From the Research

Medical Use of Monosodium Gluconate

• Monosodium gluconate is not directly mentioned in the provided studies, however, calcium gluconate is discussed as a treatment for hypocalcemia.
• The medical use of calcium gluconate includes:
  • Treatment of hypocalcemia in critically ill patients 2, 3, 4
  • Prevention of hypocalcemic reactions during therapeutic plasma exchange 5
  • Treatment of various conditions such as fluoride or oxalic acid poisoning, decreased myocardial contractility, and acute allergic conditions 6
• Calcium gluconate is preferred over calcium chloride due to its lower irritation of the vessel wall and better compatibility with other nutrients in parenteral nutrition 6

Dosage and Administration

• The dosage of calcium gluconate varies depending on the severity of hypocalcemia, with 1-2 g used for mild hypocalcemia and 2-4 g used for moderate to severe hypocalcemia 2, 3, 4
• Calcium gluconate is typically infused at a rate of 1 g/h in a small-volume admixture 2, 3, 4
• The efficacy of calcium gluconate therapy can be assessed by monitoring serum ionized calcium concentrations, which should be performed at least 10 hours after completion of the infusion 2