Side Effects of Thiamine 100 mg Daily for 2 Weeks in Soft Tissue Injury
Thiamine (vitamin B1) 100 mg daily for 2 weeks is generally safe with minimal risk of side effects in patients with soft tissue injuries. 1
Safety Profile of Thiamine
Thiamine is a water-soluble vitamin with a favorable safety profile at the dose of 100 mg daily:
- Excess thiamine is readily excreted in urine 2
- No established upper limit for thiamine toxicity has been determined 2
- 100 mg daily falls within the recommended maintenance dose range (50-100 mg/day) for patients with proven thiamine deficiency 2
Potential Side Effects
While rare at oral doses of 100 mg daily, potential side effects may include:
Common/Minor Side Effects
- Generally well-tolerated with minimal side effects at this dose
- Some patients may experience mild gastrointestinal discomfort
Rare/Serious Side Effects
- Hypersensitivity reactions (more common with repeated injections rather than oral administration) 1
- Pruritus
- Urticaria
- Feeling of warmth
- Restlessness
Important Considerations
- Severe adverse reactions like anaphylaxis are extremely rare and typically associated with intravenous administration rather than oral dosing 1
- Doses exceeding 400 mg (4 times higher than the proposed dose) may cause nausea, anorexia, and mild ataxia 2
Clinical Context for Soft Tissue Injuries
For patients with soft tissue injuries specifically:
- No evidence suggests thiamine supplementation poses additional risks in this population
- The proposed dose (100 mg daily) is well below levels associated with toxicity
- The short duration (2 weeks) further minimizes risk of adverse effects
Monitoring Recommendations
While adverse effects are rare, clinicians should:
- Be aware of the possibility of hypersensitivity reactions, especially in patients with previous adverse reactions to vitamins or supplements
- Discontinue thiamine if any signs of allergic reaction occur
- No special monitoring is required for most patients taking oral thiamine at this dose
Conclusion
The 100 mg daily dose of thiamine for 2 weeks represents a safe therapeutic approach with minimal risk of side effects in patients with soft tissue injuries. The water-soluble nature of thiamine means excess is readily excreted, contributing to its favorable safety profile at this dosage.