Differential Diagnosis for Squak in Heart Sound

• Single most likely diagnosis
  • Mitral Regurgitation: A squak or a mid-systolic click can be heard in patients with mitral valve prolapse, which often leads to mitral regurgitation. This condition is relatively common and can cause a variety of heart sounds, including a squak.
• Other Likely diagnoses
  • Tricuspid Regurgitation: Although less common than mitral regurgitation, tricuspid regurgitation can also produce abnormal heart sounds, including a squak, due to the improper closure of the tricuspid valve.
  • Pulmonary Stenosis: This condition, characterized by the narrowing of the pulmonary valve, can lead to abnormal heart sounds, including a squak or a click, as blood flows through the narrowed valve.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Aortic Dissection: Although rare, an aortic dissection can cause a new, abnormal heart sound, including a squak, due to the disruption of the aortic wall. This is a life-threatening condition that requires immediate attention.
  • Endocarditis: Infective endocarditis can cause valve dysfunction, leading to abnormal heart sounds, including a squak. This condition is serious and can be life-threatening if not treated promptly.
• Rare diagnoses
  • Ebstein's Anomaly: A congenital heart defect characterized by an abnormal tricuspid valve, which can cause a variety of heart sounds, including a squak.
  • Hypertrophic Cardiomyopathy: A condition characterized by thickening of the heart muscle, which can lead to abnormal heart sounds, including a squak, due to the obstruction of blood flow.