Differential Diagnosis for Rash on Upper Lip Area

• Single most likely diagnosis
  • Contact dermatitis: This is a common condition that occurs when the skin comes into contact with an irritant or allergen, such as certain ingredients in cosmetics, soaps, or metals. The upper lip area is a frequent site for contact dermatitis due to the use of various products like lip balms, lipsticks, or fragrances.
• Other Likely diagnoses
  • Acne: Acne can occur on the upper lip area, especially in individuals with oily skin or those prone to acne. It may be exacerbated by the use of comedogenic products.
  • Eczema (atopic dermatitis): Eczema can affect any part of the body, including the face. The upper lip area can be involved, especially in individuals with a history of atopic diseases.
  • Impetigo: A contagious bacterial skin infection that can cause red sores on the face, including the upper lip area, often in children.
  • Cold sore (herpes simplex): Although typically found on the lower lip, cold sores can occasionally appear on the upper lip, especially if the individual has a history of herpes simplex virus infections.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Lupus: Systemic lupus erythematosus (SLE) can cause a butterfly-shaped rash across the cheeks and nose, which might include the upper lip area. Missing this diagnosis could lead to delayed treatment of a potentially serious autoimmune disease.
  • Sarcoidosis: This condition can cause skin lesions, including on the face, and might involve the upper lip area. It's crucial to diagnose sarcoidosis due to its potential to affect other organs.
  • Basal cell carcinoma or other skin cancers: Although less common, skin cancers can present as a rash or lesion on the upper lip. Early detection is critical for effective treatment.
• Rare diagnoses
  • Sjögren's syndrome: An autoimmune disorder that can cause skin rashes, among other symptoms, and might rarely involve the upper lip area.
  • Melkersson-Rosenthal syndrome: A rare neurological disorder that can cause facial paralysis, swelling of the face and lips, and the development of folds and furrows in the tongue, which might include a rash on the upper lip.
  • Angioedema: A condition characterized by the rapid swelling of the skin and mucous membranes, which can sometimes present as a rash or swelling on the upper lip, often as part of an allergic reaction.