What are the steps for placing a central line?

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Last updated: October 29, 2025View editorial policy

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Steps for Placing a Central Line

Central line placement should follow a systematic six-step approach using real-time ultrasound guidance to reduce complications and increase success rates. 1, 2

Preparation and Equipment

  • Gather necessary equipment including sterile drapes, personal protective equipment (hat, mask, sterile gloves, sterile gown), ultrasound machine with high-frequency linear probe, sterile ultrasound probe cover, sterile gel, and central venous catheter kit 1, 2
  • Position the patient appropriately: Trendelenburg position for internal jugular or subclavian approach to increase venous filling; reverse Trendelenburg for femoral approach 3, 1
  • For internal jugular vein access, minimize head rotation to reduce arterial-venous overlap 3, 1

Six-Step Approach to Central Line Placement

Step 1: Identify Anatomy of Insertion Site and Localize the Vein

  • Use ultrasound to identify the target vein, adjacent artery, and surrounding anatomic structures 3, 1
  • Check for anatomic variations using both short-axis (transverse) and long-axis (longitudinal) views 3, 2
  • Perform this step before prepping and draping the puncture site 3

Step 2: Confirm Patency of the Vein

  • Use compression ultrasound to exclude venous thrombosis 3
  • Apply color Doppler imaging and Doppler flow measurements to confirm vein patency and quantify blood flow 3

Step 3: Use Real-time Ultrasound Guidance for Puncture

  • Implement aseptic technique: large sterile drape, sterile barriers (hat, mask, gloves, gown), sterile ultrasound probe cover, and sterile gel 3
  • Position yourself so the insertion site, needle, and ultrasound screen are in your line of sight 3
  • Use "single-operator technique" - hold ultrasound probe with non-dominant hand while advancing needle with dominant hand 3
  • Choose either short-axis/out-of-plane or long-axis/in-plane approach 3
  • Constantly visualize the needle tip during approach and puncture 3, 4

Step 4: Confirm Needle Position in Vein

  • Verify that the needle tip is placed centrally in the vein before advancing the guidewire 3
  • Visualize the needle tip in both short-axis and long-axis views if possible 3, 4

Step 5: Confirm Wire Position in Vein

  • Confirm correct guidewire position in both short-axis and long-axis ultrasound views 3
  • Ensure the guidewire is fully visible and accounted for during the procedure 5

Step 6: Confirm Catheter Position in Vein

  • After catheter placement, confirm correct position in the vein using ultrasound in both short-axis and long-axis views 3
  • Verify final catheter tip position at the cavoatrial junction via chest radiograph 2

Common Pitfalls and How to Avoid Them

  • Relying solely on anatomical landmarks significantly increases complication risk, especially with anatomic variations 1, 4
  • Failing to verify venous placement can lead to accidental arterial cannulation - always confirm with ultrasound, manometry, or pressure waveform 1, 4
  • Incomplete visualization of the needle tip can lead to posterior vessel wall puncture - maintain needle tip visualization throughout the procedure 3, 4
  • Guide wire loss is a serious complication - always maintain control of the guidewire and verify complete removal 5
  • Inadequate sterile technique increases infection risk - strictly adhere to maximal barrier precautions 3, 4

Special Considerations

  • For patients with difficult vascular access, ultrasound guidance significantly reduces procedure time and number of attempts 6
  • Consider using echogenic needles, plastic needle guides, or ultrasound beam steering when available to increase success rates 4
  • If unintended arterial cannulation occurs with a large-bore catheter, leave the catheter in place and consult vascular surgery or interventional radiology immediately 1
  • For suspected pneumothorax, use ultrasound to detect bilateral lung sliding before and after insertion of internal jugular and subclavian vein catheters 4

References

Guideline

Central Line Placement: Best Practices and Technique

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Central Venous Pressure Monitoring Setup and Guidance

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Ultrasound guidance versus the landmark technique for the placement of central venous catheters in the emergency department.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2002

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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