What domains are affected in individuals with schizophrenia spectrum disorder?

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DSM-5 Schizophrenia Spectrum Disorder Domains

The correct answer is A: delusions, hallucinations, disorganized thinking, disorganized or abnormal behavior, and negative symptoms—these are the five core symptom domains that define schizophrenia spectrum disorders according to DSM-5 and ICD-11 diagnostic frameworks. 1

Core Symptom Domains

The schizophrenia spectrum is characterized by abnormalities across five specific domains:

  • Positive symptoms including delusions and hallucinations, which represent the most recognizable features but have the lowest expected influence on overall functioning 2
  • Disorganized thinking (thought disorder) manifesting as loose associations, illogical thinking, and impaired discourse abilities 3
  • Disorganized or abnormal behavior including bizarre behavior and catatonic symptoms 3, 4
  • Negative symptoms encompassing five specific domains: avolition, anhedonia, asociality, blunted affect, and alogia 1

Dimensional Assessment Framework

ICD-11 and modern diagnostic approaches use dimensional symptom specifiers to describe current severity across six domains:

  • Positive symptoms (delusions, hallucinations) 1
  • Negative symptoms (avolition, anhedonia, asociality, blunted affect, alogia) 1
  • Depressive symptoms 1
  • Manic symptoms 1
  • Psychomotor symptoms 1
  • Cognitive symptoms 1

Each domain is rated on a 4-point scale from "not present" to "present and severe" 1

Why Other Options Are Incorrect

Option B is incorrect because eye movement disorders and "social relaxation problems" are not recognized DSM-5 diagnostic domains for schizophrenia spectrum disorders.

Option C is incorrect because it mentions "positive symptoms" as a separate category rather than recognizing that delusions and hallucinations ARE the positive symptoms, and it omits disorganized thinking as a distinct domain.

Option D is incorrect because sleep disturbances and speech disorders are not among the five core diagnostic domains, though disorganized speech is part of the disorganized thinking domain 3

Clinical Significance of Domains

  • Negative symptoms affect approximately 40% of patients and show the strongest relationship to functional outcomes, with anhedonia demonstrating the highest centrality and connections to multiple functional domains 5, 2
  • Positive symptoms (delusions, hallucinations) are common, occurring in 42-69% of patients, but typically occur alongside other symptom domains rather than in isolation 6
  • Cognitive symptoms affect approximately 80% of patients and contribute substantially to illness burden, though they lack specific items in traditional rating scales like PANSS 1, 5

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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