From the Guidelines
Posterior radial fissuring on MRI is most likely associated with polymicrogyria, a highly heterogeneous cortical malformation characterized by an abnormality in the distal radial glia, pia, or arachnoid, as described in the study by 1. The condition can result from various genetic and non-genetic causes, including chromosomal abnormalities, single gene mutations, in utero infections, trauma, exposure to teratogens, and arterial ischemic infarcts. Key characteristics of polymicrogyria include:
- Abnormal folding of the neuronal band
- Premature fusion of adjacent gyri
- Laminar necrosis of the developing cortex
- Altered physical properties of the thickened leptomeninges exerting mechanical constraints on the developing cortex The most common location of polymicrogyria involves the Sylvian fissures, particularly the posterior aspect, and can spread to other regions of the cerebral cortex. On MRI, polymicrogyria can appear as a thick and coarse or fine and delicate cortical surface with shallow or deep sulci, and its appearance may vary depending on the stage of maturity and myelination of the brain. It is essential to consider the clinical symptoms and correlate them with MRI findings, as polymicrogyria can be present in asymptomatic individuals, and its natural history can vary. Treatment and management of polymicrogyria should be individualized and may involve a multidisciplinary approach, including neurology, genetics, and rehabilitation services, as described in the study by 1.
From the Research
Posterior Radial Fissuring on MRI
There are no research papers to assist in answering this question, as the provided studies focus on the use of levetiracetam for seizure prophylaxis and treatment of epilepsy, lumbar radiculopathy, and other neurological conditions, but do not mention posterior radial fissuring on MRI.
- The studies 2, 3, 4, 5, 6 discuss the efficacy, dosing, and adverse events associated with levetiracetam, but do not provide information on posterior radial fissuring on MRI.
- None of the studies mention MRI findings or posterior radial fissuring in relation to levetiracetam or any other condition.
- Therefore, there is no relevant information available to answer the question about posterior radial fissuring on MRI based on the provided studies.