Cerebrolysin Dosing Frequency
Cerebrolysin is typically administered once daily via intravenous infusion for 10-21 consecutive days, with the most common treatment duration being 21 days.
Standard Dosing Schedule
Acute Ischemic Stroke
- Cerebrolysin is given as a single daily intravenous infusion of 30-50 mL for 10-21 consecutive days, with treatment initiation within 72 hours after stroke onset 1
- The typical protocol uses 15-30 mL daily for 21 days in acute middle cerebral artery stroke 2
- Treatment should begin within 72 hours of symptom onset for optimal efficacy 1
Dementia (Alzheimer's Disease and Vascular Dementia)
- Cerebrolysin is administered at 30 mL once daily via intravenous infusion, with an average treatment duration of 17.8 days in clinical practice 3
- Treatment courses typically last 10-28 weeks depending on the severity and type of dementia 4
- The medication is given as a single daily infusion, not divided into multiple doses throughout the day 3
Dose-Response Relationship
- Higher doses (≥2.5 mL/kg) demonstrate significantly better neurological recovery compared to lower doses, though differences between effective doses above this threshold are not statistically significant 5
- Doses of 5.0 mL/kg showed additional benefit in reducing infarct volume beyond functional improvement 5
- The dose-dependent effect is significant (p < 0.001) for neurological outcomes 5
Treatment Duration Considerations
- Longer treatment courses (21 days) are preferred over shorter durations (10 days) for acute stroke, as the number needed to treat for clinically relevant changes is 7.7 (95% CI 5.2 to 15.0) 1
- Timely pharmacological intervention leads to best therapeutic results, with younger, less severely affected patients showing significantly larger improvements (p < 0.05) than older, more seriously ill patients 3
- The medication demonstrates comparable safety to placebo across all dosing regimens studied 1