Magnesium Sulfate is NOT Used for Rat Poisoning
There is no established role for magnesium sulfate in treating rodenticide (rat poison) toxicity in humans, and the available evidence does not support its use for this indication.
Critical Clarification of the Clinical Question
The question appears to contain a fundamental misunderstanding. If you are asking about:
- Treating a human patient with rat poison (rodenticide) ingestion: Magnesium sulfate has no role in standard rodenticide toxicity management 1
- Treating magnesium sulfate toxicity itself: The antidote is calcium, not more magnesium 1, 2
Standard Rodenticide Poisoning Management
For actual rat poison ingestion in humans, treatment depends on the specific rodenticide type:
- Anticoagulant rodenticides (warfarin-type): Vitamin K is the treatment, not magnesium 1
- Bromethalin, cholecalciferol, or other non-anticoagulant rodenticides: Supportive care and activated charcoal (1-2 g/kg PO) within appropriate timeframes 1
- Consultation with poison control is strongly encouraged (National Poison Control Center: 800-222-1222) 1
If Magnesium Toxicity is the Actual Concern
Calcium is the immediate antidote for magnesium sulfate toxicity, not additional magnesium 1, 2:
- Calcium chloride 20 mg/kg (0.2 mL/kg of 10% solution) IV/IO given slowly for hypermagnesemia 1
- Calcium should be immediately available whenever magnesium sulfate is administered 2
- Stop magnesium administration if toxicity develops 1
Common Pitfall to Avoid
Do not confuse magnesium sulfate's legitimate uses (eclampsia, torsades de pointes, severe asthma) with rodenticide poisoning management 2, 3. These are completely separate clinical scenarios with no overlap in treatment protocols.
If this question pertains to veterinary medicine or animal research, the toxicology studies show rat LD50 values of 174-206 mg/kg IV for magnesium sulfate itself 4, but this information is irrelevant to treating poisoning from rodenticides.