From the Guidelines
There is no established relationship between progesterone and Attention Deficit Hyperactivity Disorder (ADHD) stimulants.
- The current evidence does not support a link between progesterone and the efficacy of ADHD stimulants, such as methylphenidate and amphetamine 1.
- First-line medications for the treatment of ADHD are psychostimulants, particularly amphetamine-based stimulants and methylphenidate, which have been shown to be effective in 70% to 80% of people with ADHD 1.
- The use of ADHD medications during pregnancy is a complex issue, and the risks of exposure to medications must be weighed against the risks of untreated or inadequately treated ADHD in pregnancy 1.
- Discontinuing psychostimulant treatment during pregnancy can lead to worse mental health outcomes and significant impairments in functioning in the pregnant individual, which may have negative impacts on the developing fetus or baby 1.
- However, there is no mention of progesterone interacting with ADHD stimulants or affecting their efficacy in the provided evidence 1.
From the Research
Relationship Between Progesterone and ADHD Stimulants
There is limited research directly exploring the relationship between progesterone and Attention Deficit Hyperactivity Disorder (ADHD) stimulants. However, we can examine the available evidence on progesterone and ADHD stimulants separately to understand their effects and potential interactions.
Effects of ADHD Stimulants
- Studies have shown that psychostimulants, such as methylphenidate and lisdexamfetamine, can improve symptoms of inattention and hyperactivity/impulsivity in individuals with ADHD 2, 3.
- These stimulants may also improve certain domains of cognition, such as memory and attention, in individuals with ADHD 2.
- However, the efficacy of psychostimulants in improving other domains of cognition, such as academic performance and executive function, remains inconclusive 2.
Effects of Progesterone
- Progesterone has been shown to have various effects on the body, including regulating menstrual cycles, maintaining pregnancy, and exerting neuroprotective effects 4, 5.
- Micronized progesterone, in particular, has been found to have beneficial effects on brain function, including alleviating symptoms of anxiety and depression, improving sleep, and enhancing working memory in peri- and menopausal women 4.
- Progesterone has also been investigated as a potential treatment for premenstrual syndrome (PMS), although the evidence is limited and inconclusive 6.
Potential Interactions
- There is no direct evidence to suggest a significant interaction between progesterone and ADHD stimulants.
- However, it is possible that progesterone may exert neuroprotective effects that could complement the cognitive-enhancing effects of ADHD stimulants.
- Further research is needed to explore the potential relationships between progesterone, ADHD stimulants, and cognitive function in individuals with ADHD.