Can meloxicam (a nonsteroidal anti-inflammatory drug, NSAID) cause a headache?

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Last updated: May 7, 2025View editorial policy

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From the Research

Yes, meloxicam can cause headaches as a side effect, as it is a nonsteroidal anti-inflammatory drug (NSAID) that affects prostaglandin production in the body, influencing blood vessel dilation and contraction in the brain. The most recent and highest quality study, 1, discusses the development of sustained drug delivery strategies for meloxicam to improve its therapeutic efficacy and safety profile, but does not specifically address the side effect of headaches. However, an earlier study, 2, mentions that the reported side effects of meloxicam are similar to those of nonsteroidal anti-inflammatory drugs (NSAIDs), but does not explicitly list headaches as a side effect.

Common Side Effects of Meloxicam

  • Stomach upset
  • Dizziness
  • Fluid retention
  • Abdominal pain
  • Anemia
  • Edema

If you experience persistent or severe headaches while taking meloxicam, you should contact your healthcare provider. They may recommend:

  • Adjusting your dosage (typically 7.5-15 mg once daily)
  • Switching to a different pain medication
  • Providing additional treatment for the headaches Staying hydrated and taking meloxicam with food may help reduce some side effects, including headaches in some cases, as suggested by the general properties of NSAIDs 3, 4, 5.

References

Research

Long-Acting Drug Delivery Technologies for Meloxicam as a Pain Medicine.

Critical reviews in therapeutic drug carrier systems, 2024

Research

Meloxicam.

Profiles of drug substances, excipients, and related methodology, 2020

Research

Acute Migraine Headache: Treatment Strategies.

American family physician, 2018

Research

Symptomatic treatment of migraine: when to use NSAIDs, triptans, or opiates.

Current treatment options in neurology, 2011

Research

Medical Treatment Guidelines for Acute Migraine Attacks.

Acta neurologica Taiwanica, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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