From the Guidelines
BHB salts may have a potential role in reducing degenerative bone changes, but current evidence is limited and more research is needed to fully understand their effects. When considering the use of BHB salts for degenerative bone changes, it is essential to prioritize a comprehensive approach that includes adequate calcium and vitamin D intake, as well as weight-bearing exercise and a diet rich in anti-inflammatory foods 1. The potential mechanism of BHB salts in supporting bone health involves reducing inflammation and oxidative stress, which contribute to bone degeneration, and may inhibit osteoclast activity while supporting osteoblasts 1. However, it is crucial to discuss BHB supplementation with a healthcare provider, especially for individuals with kidney issues, diabetes, or those taking medications that might interact with ketone supplements. Key considerations for BHB salt supplementation include:
- Dosage: 5-12 grams per day divided into 2-3 doses
- Duration: at least 8-12 weeks for potential benefits
- Combination with other therapies: calcium (1000-1200mg daily), vitamin D (1000-2000 IU daily), weight-bearing exercise, and a diet rich in anti-inflammatory foods
- Potential interactions: kidney issues, diabetes, and medications that might interact with ketone supplements. Given the limited evidence on BHB salts and degenerative bone changes, it is essential to rely on the most recent and highest-quality studies, such as those published in reputable journals like Nature Reviews Gastroenterology and Hepatology 1 and Annals of Oncology 1.
From the Research
BHB Salts and Degenerative Bone Changes
There is limited research available on the topic of BHB salts and degenerative bone changes. The provided studies do not directly address the relationship between BHB salts and degenerative bone changes.
- The studies focus on the health benefits of omega-3 fatty acids 2, 3, 4 and the potential therapeutic effects of beta-hydroxybutyrate (BHB) in traumatic brain injury 5 and its measurement in emergency department settings 6.
- None of the studies specifically investigate the relationship between BHB salts and degenerative bone changes.
- Therefore, there is no direct evidence to support or refute a relationship between BHB salts and degenerative bone changes based on the provided studies.