From the FDA Drug Label
Miscellaneous: ... weight decreased, weight increased. The average weight gain associated with progesterone therapy for menopausal symptoms is not explicitly stated in the drug label. Key points:
- Weight increase is listed as a possible adverse reaction.
- The frequency of weight increase is not specified.
- No specific amount of weight gain is mentioned. 1
From the Research
Progesterone therapy for menopausal symptoms is typically associated with a modest weight gain of approximately 1-5 pounds (0.5-2.3 kg) on average, though individual responses vary considerably. This weight gain is generally less pronounced than with estrogen-progestin combination therapies. The weight changes are often due to fluid retention rather than increased fat mass, particularly in the first few months of treatment. Progesterone can influence appetite regulation and may cause some women to experience increased hunger. The weight gain tends to be more noticeable when using synthetic progestins (like medroxyprogesterone acetate) compared to bioidentical progesterone. To minimize weight effects, consider using the lowest effective dose, maintaining regular physical activity, following a balanced diet, and discussing with your healthcare provider if weight gain becomes concerning. The weight changes typically stabilize after the initial adjustment period of 3-6 months as the body adapts to the hormonal changes 2.
Some key points to consider:
- The menopausal transition is associated with a range of symptoms, including hot flashes, night sweats, and genitourinary symptoms, which can be effectively managed with hormonal and nonhormonal treatments 3.
- Progesterone therapy is often used in combination with estrogen to prevent endometrial hyperplasia and cancer, and the choice of progestogen can impact the risk of cardiovascular and metabolic disease 4.
- The impact of menopause on body weight and composition is complex, and while weight gain is not directly attributed to menopause, the hormonal changes can lead to increased abdominal fat and metabolic sequelae 5.
- Estrogen therapy may help prevent some of the menopause-related changes in body composition, but further studies are needed to identify the women most likely to benefit from hormone therapy 5.
Overall, the management of menopausal symptoms, including weight gain, requires a comprehensive approach that takes into account the individual woman's health status, symptoms, and preferences, as well as the potential benefits and risks of different treatment options 2, 3, 4, 5.