What are the recommended topical medications for the treatment of hordeolum?

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Last updated: June 14, 2025View editorial policy

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From the Guidelines

Topical antibiotics, such as erythromycin or bacitracin ointment, are the primary recommended medications for treating hordeolum, applied to the affected eyelid margin 2-4 times daily for 7-10 days. The treatment of hordeolum, also known as a stye, typically involves addressing the bacterial infection that causes the condition [ 1 ].

Key Considerations

  • Before applying any medication, gently cleansing the eyelid with warm compresses for 10-15 minutes, 3-4 times daily, can help soften and drain the infected material.
  • Patients should apply the ointment with clean hands or a sterile cotton swab to prevent spreading the infection.
  • It is essential to avoid sharing towels or washcloths to minimize the risk of transmission.

Treatment Options

  • Erythromycin ophthalmic ointment (0.5%) or bacitracin ophthalmic ointment are commonly used topical antibiotics for treating hordeolum [ 1 ].
  • For more severe cases, combination antibiotic-steroid preparations like neomycin-polymyxin B-dexamethasone may be used, but these should be prescribed with caution due to potential steroid side effects.

Monitoring and Follow-Up

  • If symptoms do not improve within 48-72 hours of treatment, or if vision changes, pain increases, or the redness spreads, medical attention should be sought as oral antibiotics may be necessary [ 1 ].

From the Research

Topical Medications for Hordeolum Treatment

  • There is limited evidence on the effectiveness of topical medications for the treatment of hordeolum 2, 3.
  • A pilot study compared the effectiveness of combined antibiotic ophthalmic solution with a placebo in the treatment of hordeolum after incision and curettage, and found no statistically significant differences between the two groups 4.
  • A retrospective review of patients treated for chalazia or hordeola found that the addition of an antibiotic to conservative measures was not associated with an increased likelihood of treatment success 5.
  • The use of antibiotics was more likely to be prescribed in emergency or acute care settings for chalazia, and older age was associated with a higher risk of receiving an antibiotic for hordeolum 5.

Recommended Topical Medications

  • There is no clear evidence to support the use of specific topical medications for the treatment of hordeolum 2, 3.
  • Combined antibiotic ophthalmic solutions, such as neomycin sulfate, polymyxin B sulfate, and gramicidin, have been studied, but their effectiveness is unclear 4.
  • Artificial tears may be used as a placebo or to help with symptoms, but their effectiveness in treating hordeolum is unknown 4.

Treatment Approaches

  • Conservative measures, such as warm compresses and lid scrubs, may be recommended for the treatment of hordeolum, but the effectiveness of these approaches is not well established 2, 3.
  • Incision and curettage may be performed in some cases, but the effectiveness of this procedure is not well studied 4.
  • The use of antibiotics is common in the treatment of hordeolum, but their effectiveness is unclear, and they may not improve treatment outcomes 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Interventions for acute internal hordeolum.

The Cochrane database of systematic reviews, 2013

Research

Interventions for acute internal hordeolum.

The Cochrane database of systematic reviews, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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