Should I offer a blood test to evaluate the patient's condition?

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Last updated: June 17, 2025View editorial policy

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From the Guidelines

Yes, you should offer a blood test to evaluate the patient's condition. Blood tests provide valuable objective data that can help establish a diagnosis, monitor disease progression, or evaluate treatment effectiveness. According to the most recent and highest quality study 1, blood tests, which may include a full blood count, kidney and liver function, C reactive protein, ferritin, B-type natriuretic peptide, and thyroid function, can help rule out serious or urgent complications, evaluate symptoms secondary to ongoing symptomatic COVID-19 or post-COVID-19 syndrome, or to look for new, unrelated diagnoses. Some key points to consider when offering a blood test include:

  • The patient's presenting symptoms and medical history
  • The potential risks and benefits of the test
  • The timing of blood collection, as some tests require fasting (typically 8-12 hours), while others can be done at any time
  • The interpretation of test results in the context of the patient's overall clinical picture, rather than in isolation. It's also important to note that while some studies suggest that routine laboratory testing may not be necessary for all patients 1, the most recent and highest quality study 1 recommends offering blood tests to evaluate the patient's condition.

From the Research

Evaluation of Patient Condition

To evaluate a patient's condition, offering a blood test can be a valuable diagnostic tool. The complete blood count (CBC) is one of the most frequently ordered laboratory tests in medicine, providing information about the production of all blood cells and identifying the patient's oxygen-carrying capacity 2.

Components of a Blood Test

A blood test, such as a CBC, includes various components, such as:

  • Red blood cell count
  • Hemoglobin
  • Hematocrit
  • Red blood cell indices
  • Reticulocyte count
  • White blood cell count and differential
  • Platelet count 2 These components can help diagnose various conditions, including anemia, certain cancers, infection, acute hemorrhagic states, allergies, and immunodeficiencies 3.

Diagnostic Tool

The CBC can be a powerful diagnostic tool when used in conjunction with a good history and physical examination, as well as with additional components of the minimum database, which include a chemistry panel and urinalysis 4. It can also provide information about the immune system through the evaluation of the white blood cell count with differential 3.

Predictive Value

Recent studies have suggested that the risk of cancer, cardiovascular disease, arteriosclerosis, type 2 diabetes, and metabolic syndrome can be predicted using CBC components, such as white blood cell count, neutrophil-to-lymphocyte ratio, hemoglobin, and platelet count 5.

Considerations

However, it is essential to consider the appropriateness of repeat testing, as unnecessary testing can result in significant costs to healthcare without compromising patient care 6. Therefore, it is crucial to evaluate the patient's condition and medical history before offering a blood test.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The complete blood count: physiologic basis and clinical usage.

The Journal of perinatal & neonatal nursing, 1997

Research

Understanding the complete blood count with differential.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2003

Research

The complete blood cell count: a powerful diagnostic tool.

The Veterinary clinics of North America. Small animal practice, 2003

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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