I have an endometrial carcinoma with a POLE c.1124G>A (p.R375Q) variant; does this constitute a POLE‑ultramutated subtype and should it change management?

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Related Questions

In a patient with endometrial carcinoma, how should the POLE exon 12 mutation c.1124G>A (p.R375Q) be interpreted regarding its pathogenic significance and impact on treatment decisions?

How is endometrial cancer classified?

Is the POLE gene exon 12 p.R375Q (c1124G>A) mutation indicative of a POLE‑ultramutated tumor?

Which POLE (DNA polymerase epsilon) mutations in endometrial carcinoma are considered true hypermutated events associated with a favorable prognosis?

What is the difference between grading and staging of endometrial carcinoma?

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