Reconstitution of Retatrutide 36mg to 2mg/mL
To achieve a concentration of 2 mg/mL from a 36 mg vial of retatrutide, you need to add 18 mL of normal saline.
Calculation Method
The calculation follows basic dilution principles where the desired concentration determines the final volume needed:
- Target concentration: 2 mg/mL
- Total drug amount: 36 mg
- Required final volume: 36 mg ÷ 2 mg/mL = 18 mL
- Volume of diluent to add: 18 mL of normal saline
Practical Considerations
Normal saline (0.9% sodium chloride) is the appropriate diluent for peptide medications, as it maintains isotonicity and stability without causing precipitation 1, 2
After adding 18 mL of normal saline to the 36 mg vial, gently swirl (do not shake vigorously) to ensure complete dissolution of the lyophilized powder
The reconstituted solution should be clear and free of particulate matter before administration
Label the vial clearly with the final concentration (2 mg/mL), date and time of reconstitution, and your initials
Storage and Stability
Once reconstituted, store the vial under refrigeration (2-8°C) and use within the timeframe specified by the manufacturer's guidelines
Protect from light and avoid freezing the reconstituted solution
Each dose can be drawn up using aseptic technique with an appropriate syringe for subcutaneous administration 3, 4, 5