Room Temperature Duration for Manthera Before Administration
Manthera (rituximab) should be removed from refrigeration and allowed to reach room temperature for 30 to 60 minutes before administration to reduce injection pain and minimize the risk of lipodystrophy. 1
Key Storage and Handling Recommendations
Pre-Administration Warming Period
Allow 30-60 minutes at room temperature before injection, as administering cold medication directly from the refrigerator can cause significant injection site pain and contribute to the development of lipodystrophy (abnormal fat distribution at injection sites). 1
The warming period should occur at ambient temperatures between 15-30°C (59-86°F), away from direct sunlight exposure. 1
Storage Guidelines
Unopened vials must be stored at 2-8°C (36-46°F) in a refrigerator without freezing. 2
Verify your household refrigerator maintains this temperature range, as many home refrigerators operate outside the recommended range. 2, 3
Never freeze Manthera, as freezing can alter the molecular structure and potentially reduce efficacy. 2
Transportation Precautions
Use insulated bags or cooler packs when transporting Manthera in hot or cold weather conditions to maintain the 2-8°C temperature range. 2, 4
Minimize time outside refrigeration during transport. 4
Pre-Injection Safety Checks
Always verify the medication is not expired before administration. 1, 2
Inspect visually for any changes in appearance including clumping, frosting, precipitation, or changes in clarity or color—do not use if any abnormalities are present. 2
Avoid exposing the medication to direct heat, light, or excessive agitation during the warming period. 2
Important Clinical Considerations
The 30-60 minute warming window represents a balance between patient comfort and medication stability. While some medications can remain at room temperature for extended periods (up to 28 days for certain insulins 1), the specific stability data for Manthera at room temperature should guide practice. The primary goal of this brief warming period is to enhance patient tolerability without compromising drug integrity.